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Ghaisas, M. M.
- Evaluation of Antihyperlipidemic Activity of Mimusops elengi L. in Triton WR- 1339 Induced Hyperlipidaemia in Rats
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Journal of Natural Remedies, Vol 8, No 2 (2008), Pagination: 132-137Abstract
Objective: The present study was undertaken to explore antihyperlipidemic effect of ethanolic extract of Mimusops elengi L. (ME) in Triton WR-1339 induced hyperlipidemia in rats. Materials and methods: The wistar rats were divided in to Normal control (NC), Hyperlipidemic group (HG), Fenofibrate group (FG), Mimusops elengi L. (ME) treated groups (100, 300, 600 mg/kg, p.o.). Hyperlipidemia in all groups was induced by single i.p. injection of Triton WR-1339 at a dose of 200 mg/kg except normal control. Result: The groups treated with Mimusops elengi L. showed significant reduction (p<0.01) in levels of triglyceride and total cholesterol as compared to HG after 7 and 24 h of induction. Even after 48 h the groups treated with Mimusops elengi L. showed significant decrease (p<0.01) in level of triglyceride in groups ME 300, ME 600 and significant decrease (p<0.05) in level of total cholesterol in groups ME 300, ME 600 respectively as compared to HG. Moreover HDL level was significantly elevated (p<0.01) in the groups ME 300, ME 600 after 7 and 24 h, however it was significantly elevated (p<0.01) only in ME 600 after 48 h of the treatment. Conclusion: Hence it can be concluded that Mimusops elengi L. has significant antihyperlipidemic effect owing to its ability to reduce the levels of total cholesterol, triglyceride and increasing the level of HDL.Keywords
Hyperlipidemia, Mimusops elengi L., Triton WR- 1339- Anti-inflammatory Effect of Cajanus indicus (Linn.) Mill. in a Murine Model of Asthma
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Journal of Natural Remedies, Vol 11, No 2 (2011), Pagination: 102-118Abstract
The present study was undertaken to explore the effects of Cajanus indicus (Linn.) Mill. on airway inflammation and oxidative stress in ovalbumin-induced inflammation and antilipoxygenase activity in a murine model of asthma. The protective effect of extract of whole plant of Cajanus indicus (Linn.) Mill. against ovalbumin induced lung inflammation and arachidonic acid induced paw inflammation was evaluated. Hydroalcoholic extract of Cajanus indicus (Linn.) Mill.(CI) showed significant inhibition of total as well as differential leukocytes in the bronchalveolar lavage (BAL) fluid at dose of 350 and 525 mg/kg, p.o. (p<0.01).Pretreatment with CI significantly restored (p<0.01) the level of GSH, SOD,CATALASE and LPO in lungs. In BAL fluid, treatment of CI significantly reduced nitric oxide and total protein level. CI significantly inhibited arachidonic acid induced paw edema (p<0.01). Hence it can be concluded that Cajanus indicus (Linn.) Mill. has significant anti-inflammatory, antioxidant and antilipoxygenase effect.Keywords
Cajanus indicus, Asthma, Antioxidant, Ovalbumin- Tectona grandis Linn Prevent the Cardiac Dysfunction in Alloxan Induced Diabetic Rats
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